Structure Based Drug Discovery, Docking, Modelling, Synthesis and Anticancer Screening of Some Novel Quinoline Derivatives

Honde, Bharat Shivaji and Rajendra, Kunkulol Rahul (2021) Structure Based Drug Discovery, Docking, Modelling, Synthesis and Anticancer Screening of Some Novel Quinoline Derivatives. Journal of Pharmaceutical Research International, 33 (62A). pp. 341-353. ISSN 2456-9119

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Official URL: https://doi.org/10.9734/jpri/2021/v33i62A35384

Abstract

A new series of (2-(substituted-phenyl) quinoline-4-yl) (3-(substituted phenyl)-5-phenyl-1H-pyrazol-1-yl) methanone derivatives was carried out docking modelling and synthesized. Purity was checked by TLC and chemical structures of synthesized compounds were elucidated by their IR, 1HNMR, MS analysis data. The synthesized compounds were screened for anticancer activity by using cell line MCF-7 (Human breast cancer cell line) correlate with docking modelling.

Item Type:	Article
Subjects:	Article Paper Librarian > Medical Science
Depositing User:	Unnamed user with email support@article.paperlibrarian.com
Date Deposited:	03 Feb 2023 10:24
Last Modified:	03 Jan 2024 06:53
URI:	http://editor.journal7sub.com/id/eprint/112

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