Nguyen, Phi Hung and To, Dao Cuong and Tran, Manh Hung (2021) Pimarane Diterpenes from Vietnamese Orthosiphon stamineus Benth. and Their Glucose Uptake Stimulatory and PTP1B Inhibitory Activities. In: Current Advances in Chemistry and Biochemistry Vol. 1. B P International, pp. 126-137. ISBN 978-93-90516-18-6
Full text not available from this repository.Abstract
Seven pimarane diterpenes (1–7) were isolated from Orthosiphon stamineus Benth. by assay-guided isolation. All of the isolates possessed a 2-deoxy-2-((7-nitro-2,1,3-benzoxadiazol-4-yl)amino)-d-glucose uptake effect in 3T3-L1 adipocytes at concentrations of 5 and 10 ?M. Most of them showed potent inhibition against protein tyrosine phosphatase 1B with IC50 values ranging from 0.33 to 9.84 ?M. In the kinetic study, all inhibition types were exposed for the examined potencies, including mixed-competitive (1), non-competitives (3 and 5), competitive (6), and uncompetitive (7). The results suggested that O. stamineus and its pimarane diterpenes might exert the hypoglycemic effect via the insulin signaling pathway targeting inhibition of protein tyrosine phosphatase 1B (PTP1B) activity. The results suggest that these active constituents from O. stamineus may be the potential natural products for the development of anti-hypoglycemic agents.
Item Type: | Book Section |
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Subjects: | Article Paper Librarian > Biological Science |
Depositing User: | Unnamed user with email support@article.paperlibrarian.com |
Date Deposited: | 07 Nov 2023 05:31 |
Last Modified: | 07 Nov 2023 05:31 |
URI: | http://editor.journal7sub.com/id/eprint/2177 |