LIPID PROFILE IN NIGERIAN OBESE DIABETIC PATIENTS

Background: Obesity is associated with dyslipidaemia thereby increasing the likelihood of various diseases, particularly coronary heart disease (CHD), type 2 diabetes, obstructive sleep apnea, certain type of cancers and osteoarthritis hence this study.

Methods: This study was carried out on two hundred and two (202) subjects, aged 20-68 yrs which comprised of fifty nine (59) obese diabetic subjects and forty five (45) obese non-diabetic patients, fifty one (51) non-obese diabetic patients and sixty (60) non-obese non-diabetics (apparent healthy volunteers) as control group. Fasting Blood Glucose (FBS, plasma lipid profile {total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), High density lipoprotein (HDL) and very low density lipoprotein (VLDL)} were estimated using standard methods.

Results: It was observed when compared that HDL and LDL in obese diabetic subjects were significantly higher than those of their control groups while the TC, TG and VLDL were not significant. LDL significantly correlated with age and BMI when obese diabetics and obese non-diabetics were compared. Mean±SD of plasma lipid profile of obese diabetic subjects on the basis of age groups and sex were not significant when compared.

Conclusion: This study confirmed that obesity and diabetes affect lipids metabolism and this abnormal lipid profile observed in this study is a proof that obesity and diabetes mellitus are associated with complications of dyslipidaemia such as coronary heart disease (CHD).