Crystallography and Biopharmaceutics of Some Antimalarials

Crystallography is a branch of science that deals with the discerning of the arrangement and bonding of atoms in crystalline solids. Crystal structural differences in the active pharmaceutical ingredient (API)/excipients in multi-source generics of antimalarials may present differences in their physicochemical properties and ultimately the rate and extent of drug absorption. Tackling the menace of the continuing spread of multi-drug resistant Plasmodium falciparum malaria may require the evaluation of the crystal structural influences of orally administered drugs on antimalarial bioavailability.