Management of Severe Aplastic Anaemia in a Jehovah’s Witness patient: The challenge and Lessons

Aplastic anaemia is a life threatening consequence of severe bone marrow failure often requiring supportive care with component blood transfusions and stem cell replacement procedures. In this case report and review of literature, the authors highlight peculiar challenges in the management of severe aplastic anaemia in patients with strong objection to blood transfusion. The impact of optimal use of blood transfusion alternative pharmacological strategies on clinical outcome indices is evaluated and relevant lessons in the management of this unique category of patients in poor resource environments are learned.