LOW BASED TRIPLE THERAPY FOR ELDERLY PATIENT WITH PRE-LIVER CIRRHOSIS HEPATITIS TYPE C CONTRIBUTES TO IMPROVE HEPATIC FUNCTIONAL RESERVE

We present the case of an 80-year-old Japanese female suffering from a genotype 1b HCV infection, with a previous history of post-treatment relapse of PEG-IFN (interferon)/ribavirin (RBV). The patient was retreated with telaprevir-based triple therapy, she achieved rapid virological response (RVR). Despite dose reduction of treatment because of adverse effect (AE), she obtained a sustained virological response (SVR). Furthermore, hepatic functional reserve improved.

This case suggests that in selected genotype 1 HCV-infected patients, a successful treatment can be obtained even with a very low dose of these therapy because of AE or reduced compliance for elderly patient with fibrosis.