Neuropsychology and Genetics of Psychotropic Drug Users - Lithuanian COMT Gene Polymorphisms Frequencies

Background: Addiction is increasing worldwide, so there is a need to study the neuropsychology and genetics of the emergence of this process. In our study, we have focused on the characteristics of the COMT gene in psychotropic drug users.

Aim of the Study: Investigation of the frequency of COMT gene polymorphisms in psychotropic drug users in Lithuania as well to review literature of addiction neuropsychology and genetics.

Materials and Methods: The study involved 73 patients aged 18 to 75 years.from InMedica Santariškės clinics who were tested for A (adenine), G (guanine) alleles and A/A, A/G and G/G COMT genotypes.

Results: The study analyzed the frequency of comt gene polymorphisms in in 73 psychotropic drug users. It was identified A/A genotypes in 17, A/G in 37, G/G in 19 participants.

Conclusion: In studied cohort we detected high rates of more rare A/A genotype , which is related to lower amount of COMT enzyme and in result higher catecholamines level.