Simultaneous radiologic isolated syndrome and glioblastoma multiforme in an adult patient.

A young known case of multiple sclerosis was evaluated with chief complaint of gradually progressed left lower limb weakness over 3 weeks. Pathologic examination of a mass in brain magnetic resonance imaging confirmed the diagnosis of glioblastoma multiforme (GBM). Given the importance of the definite diagnosis of malignant glioma and its effect on patient’s management, GBM should be considered as a differential diagnosis in cases with coexisting mass like lesion and demyelinating plaques.