Anti-candida and anti-enzyme activity and cytotoxicity of 2-phenyl-4H-chromen-4-one

This study determined the fungicidal concentration (MFC), anti-enzymatic (production of proteinases and phospholipase), and cytotoxic activities of 2-phenyl-4H-chromen-4-one against different strains of Candida sp. The results were: MIC> 62.5 µg\ml and MFC>250 µg\ml for C. albicans; MIC/MFC = 31.25 µg\ml for C. parapsilosis; MIC/MFC= 62.5 µg/ml for C. famata; MIC/CFM =125 µg\ml for C. glabrata and MIC = 15.62 µg\ml for C. lipolytica. Values ​​for phospholipase and proteinase before and after exposure of yeast to the compound had no statistical differences. For the cytotoxicity test, there were no statistical differences between the tested and control groups. Data from this study provide evidence that 2-phenyl-4H-chromen-4-one could be an alternative source for the treatment of fungal infections caused by Candida.